Allison shafer md proton email4/2/2023 ![]() ![]() 17 Thus, while we cannot expressly mimic the exquisite architectures of natural peptides, we are motivated to seek methods by which diverse metallohelices might be rapidly accessed and new biological properties discovered and optimised. amyloid-β aggregation, 12, 14 enzyme activity 15, 16 and ice recrystallization. With this in mind we have developed several classes of water-compatible, optically pure metallohelix compounds, 9– 11 each of which has unique properties, including a growing list of peptide-like behaviours: binding of DNA motifs, 12 anticancer activity, 5, 11, 13 and the inhibition of e.g. signalling, structural and host-defence roles, 5– 7 some such metallofoldamers 8 have similar dimensions and charge. ![]() Indeed, while their underlying chemistry is very different to that of the small cationic α-helical peptide units that are deployed in nature for e.g. Lehn envisaged in the original report 1 that helicates 2– 4 – self-assembling multimetallic coordination compounds – may find uses in biochemistry. ![]()
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